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Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL (PR Newswire via Yahoo! Finance) TopoTarget A/S announced that a positive reply from the FDA was received on a Special Protocol Assessment for a phase III trial for belinostat in PTCL . This pivotal trial is to enrol approximately 120 patients and is to begin in Q4 2008.us.rd.yahoo.com